Topic: autosomal recessive primary microcephaly

Mechanisms controlling human brain development, despite their relevance, remain poorly understood, given the challenges of studying human embryos and the developmental divergence from animal models. Human (h)iPSC-based in vitro models can be used to understand mechanisms of human brain development and its possible alterations, thereby bypassing substantial interspecies differences. Indeed, human brain complexity suggests tightly regulated and detailed developmental steps, which can be undermined by several insults leading to severe pathologies.Conventional 2D-cell cultures do not recapitulate