The importance of high-density microelectrode arrays for recording multi-scale extracellular potential and label-free characterization of network dynamics in iPSC-derived neurons
Zhuoliang (Ed) Li, Francesco Modena, Elvira Guella, Anastasiia Oryshchuk, Laura D’Ignazio, Praveena Manogaran, Marie Obien · FENS Forum 2024
Advances in the development of microelectrode arrays (MEAs) for in-vitro electrophysiological recordings have enabled the characterization of multi-scale behavior in neuronal networks, ranging from subcellular level to network dynamics. Such devices are fundamental for studying the phenotype of neurological disorders and for drug discovery, providing unique insights into the complexity of neuronal networks. Electrode density, spacing, and size influence the signal quality, noise level, and sensitivity. To properly characterize the full behavior of neuronal networks, MEAs must combine single-ce
ePoster · Neuroscience