Topic: axonal demyelination

Multiple sclerosis (MS) is a chronic demyelinating disease estimated to affect 2.8 million people globally. Recent human studies indicate that MS is not merely a consequence of demyelination, but it also involves an intricate neuronal component, which remains poorly understood. Here, we employed the experimental autoimmune encephalomyelitis (EAE) mouse model of MS to study the neuronal response during autoimmune neuroinflammation, with a particular focus on the prodromal phase, which precedes axonal demyelination. We implemented Targeted Recombination in Active Populations (TRAP) and a compreh