Cellular and molecular characterization of serotonergic synapses in a mouse model of depression and raphe synucleinopathy
Unai Sarriés-Serrano, Lluis Miquel-Rio, Sarka Jelinkova, Vincent Paget-Blanc, Verónica Paz, J Javier Meana, Etienne Herzog, Analia Bortolozzi · FENS Forum 2024
AIMS: Anxiety and depression affect 35-50% of patients with Parkinson's disease (PD). In the serotonin (5-HT) system alpha-synuclein (a-Syn) aggregates are present and functional changes are involved in the PD prodromal phase and contribute to non-motor symptoms. Using a mouse model of depression and synucleinopathy in raphe 5-HT neurons, we aim to evaluate: 1- behavioral phenotype, 2- synaptic changes in prefrontal cortex and striatum, and 3- possible sex-based differences. METHODS: Recombinant adeno-associated viral vectors (AAV2/5) encoding wild-type human a-Syn (h-a-Syn) were infused in r
ePoster · Neuroscience