Improving the functionality of microscale electrodes implanted in neural tissue with upconverting nanoparticles
Levente Víg, Ágoston Csaba Horváth, Bence Csernyus, Anita Zátonyi, Márton Bojtár, Péter Kele, Fürjes Péter, László Péter, Zoltán Fekete · FENS Forum 2024
In this research, the primary focus was on the development and characterization of a drug delivery system, that integrates micro electrocorticography (ECoG) arrays with upconverting nanoparticles (UCNP) to create a surface-modified, light-triggerable nanosystem for nervous tissue application. Methodology involves using a soft ECoG with a silicone substrate and Pt/Ir measuring sites. First the electrode surface is exposed to oxygen plasma then azide groups bind to it. Simultaneously, the UCNP exterior is modified with an aminosilane layer then a BCN-NHS linker compound. This linker attaches the
ePoster · Neuroscience