Topic: BACE1 inhibitor

Alzheimer’s disease is a progressive age-associated neurodegenerative disease, characterised by the presence of two key neuropathological hallmarks; amyloid-β plaques and neurofibrillary tangles. Understanding how amyloid-β behaves “in vivo” prior to symptomatic onset is an important question that has previously only been inferred by peripheral measurements (CSF, PET). Here we use human brain slice cultures to model aspects of amyloid-β AD pathology, by both assessing how endogenous properties and pathology relate to patient characteristics, and by induced perturbations using pharmacological t