Assessing the therapeutic potential of antidepressant and anti-inflammatory drugs in an inflamed depression mouse model: A comparative study of efficacy
Aurelia Viglione, Naomi Ciano Albanese, Giulia Fiorentini, Silvia Poggini, Anna Poleggi, Igor Branchi · FENS Forum 2024
Major depressive disorder (MDD) is a widespread mental health condition affecting over 280 million people worldwide and is a major contributor to the global burden of disease. Despite selective serotonin reuptake inhibitors (SSRIs) being the first line of treatment for MDD, 30-40% of patients do not achieve remission, with chronic low-level inflammation linked to treatment resistance. This study aimed to evaluate the efficacy of the anti-inflammatory drug ibuprofen compared to the SSRI fluoxetine in a mouse model of inflamed depression. The objective was to explore whether anti-inflammatory dr
ePoster · Neuroscience