The mitotic protein CENP-F, implicated in microcephaly, relocalises to key cellular structures during neurodifferentiation and ciliogenesis
Ludovica Altieri, Vincenzo Costanzo, Silvia Gasparini, Pietro Cirigliano, Carlo Brighi, Cecilia Mannironi, Patrizia Lavia · FENS Forum 2024
Neurodevelopmental disorders (NDDs) are often associated with mutations in mitotic genes rather than in genes specifying neuronal functions. Several mitotic regulators are functionally repurposed to new roles during neurodifferentiation. CENP-F, a kinetochore- and microtubule-interacting protein with well-characterised mitotic functions, is being growingly identified for harbouring mutations in primary microcephaly and in the Strømme syndrome, an NDD classified as a ciliopathy. The mechanism through which mutant CENP-F contributes to these NDDs remains elusive.To gain insight into the implicat
ePoster · Neuroscience