Functional changes in the basal ganglia-thalamus-cortex loop in L-DOPA-induced dyskinesia in a mouse model of unilateral Parkinson's disease
Tomokazu Tsurugizawa, Yuki Nakamura, Yukari Nakamura, Assunta Pelosi, Jean-Antoine Girault, Denis Hervé · FENS Forum 2024
Advances in MRI imaging techniques such as diffusion tensor imaging and functional magnetic resonance imaging (fMRI) make it possible to noninvasively measure the structure of cerebral white matter fibers and neural activity in the brain. Clinical application of these techniques is expected for early diagnosis of Parkinson's disease and evaluation of pathophysiology and treatment efficacy. In this study, we used MRI to examine changes in functional connectivity in [JAG1] mice in which 6-hydroxydopamine (6-OHDA) was unilaterally injected into the medial forebrain bundle of the mouse and which d
ePoster · Neuroscience