Topic: basal synaptic transmission

Pain is a complex sensory and emotion experience that typically facilitates a learning event so that an individual may avoid future harm. However, in a chronic pain context, pain that is experienced at inappropriate times no longer provides a useful function and may impair learning. Cognitive deficits including difficulties with learning and memory recall have been well documented in the clinic but pre-clinical data is lacking and the neural basis remains poorly understood. Using a chronic constriction injury (CCI) model of neuropathic pain in mice, combined with ex vivo electrophysiology and