Encoding and retrieval of a contextual fear memory evoke divergent expression of immediate-early genes Arc and c-Fos
Nicholas Bulthuis, Liliette Quintana, Michelle Stackmann, Christine Ann Denny · FENS Forum 2024
The encoding or retrieval of a contextual fear memory recruits the activity of thousands of neurons across the mammalian brain. This ensemble of cells is often identified by immediate-early genes (IEGs), which are expressed following neuronal activity, but the extent to which the expression pattern of one IEG reflects another is unclear. Here, we examined the IEGs Arc/Arg3.1 and c-Fos across several brain regions during fear memory encoding or retrieval. Mice were administered a 3-shock contextual fear conditioning (CFC) paradigm and sacrificed 1h later (encoding), 1 h after context re-exposur
ePoster · Neuroscience