The inhibition of oligodendrocyte remyelination after spinal cord injury results in cognitive impairment and delayed/inhibited locomotor recovery in aged mice
Sarah Wheeler, Bethany Kondiles, Sohrab Manesh, Jie Liu, Min Lu, Wolfram Tetzlaff · FENS Forum 2024
In western nations, the average age of spinal cord injury (SCI) has increased and is equally spread out between 20-65 years old. SCI typically causes focal demyelination of spared axons near the site of injury. Surprisingly, we did not find locomotor impairment after SCI when remyelination was inhibited in young mice (Duncan et al. 2018, Nat. Comm). However, the functional impact of remyelination after SCI at an advanced age is unknown. Here, we assessed the importance of remyelination for locomotor recovery, cognitive function, and anxiety in young (3-5 month) and aged (15-18 month) mice of b
ePoster · Neuroscience