Topic: Bayesian inference model

Perception balances what we sense with what we expect. To maintain accuracy, our brains must continuously update sensory expectations when predictions don't match reality. To investigate this, we trained mice on an auditory detection task with hidden switches in stimulus probability across trials. Mice dynamically adjusted their decision thresholds, tracking these changing sound probabilities. We monitored dopamine in the tail of the striatum (TS), a region at the interface of sensory processing and action selection that receives direct auditory cortex inputs. Given mesolimbic dopamine's estab