Investigation of blood-brain barrier transporter dysfunction in sporadic Alzheimer's disease: Insights from patient iPSC-derived models
Juliana Cristina da Silva Chaves, Anthony R White, Lotta E Oikari · FENS Forum 2024
Alzheimer's disease (AD) is a prevalent form of dementia, primarily affecting those aged 65 and older, known as late-onset or sporadic AD (sAD). It is characterized by the accumulation of βeta-amyloid protein aggregates and tau protein neurofibrillary tangles. Recent research highlights the crucial link between AD and dysfunction in the blood-brain barrier (BBB), primarily composed of brain endothelial cells (BECs), pericytes, and astrocytes, which regulate homeostasis in the brain. Transporter-mediated regulation at the BBB is pivotal, with dysregulation implicated in AD pathology. Non-invasi
ePoster · Neuroscience