ePoster · Neuroscience
Improving glutamate metabolism to simultaneously address energetic failure and cell dysfunctions in Alzheimer’s disease
Tiziano Serfilippi, Alessandra Preziuso, Giorgia Cerqueni, Valentina Terenzi, Simona Magi, Vincenzo Lariccia, Silvia Piccirillo · FENS Forum 2024
Perturbations in brain cell metabolism are consistently interwoven with neurodegenerative disorders like Alzheimer's disease (AD)(1). In particular, dysfunctions of mitochondrial bioenergetics incite severity of AD pathology (2), whereas proof-of-concept evidence indicates that glutamate can feed mitochondrial ATP synthesis, thereby preventing deadly derangements in Ca2+ and redox homeostasis in different neurodegenerative models (3;4).In this work, we tested a pharmacological approach to stimulate the glutamate dehydrogenase (GDH) function with the allosteric activator 2-Aminobicyclo-(2,2,1)-