Topic: BChE inhibition

Recently, a central role of butyrylcholinesterase (BChE) in pathogenesis of obesity has been proposed. As BChE was shown to inactivate a hunger hormone, ghrelin, it has been suggested to control appetite and glucose metabolism by regulating ghrelin signaling in hypothalamus. The aim of our study was therefore to investigate the relationship between obesity induced by high-fat/high-fructose diet and BChE activity. We studied impact of the diet-induced obesity on serum BChE and vise-versa an effect of BChE inhibition on obesity development. Adults male Wistar rats were fed with standard or high-