Evaluation of running wheel behavior as a reliable marker for severity assessment and humane endpoint detection in a rat model with intracranial tumor
Alina Ottlewski, Christine Häger, Mesbah Alam, Elvis J. Hermann, Franck Fogaing Kamgaing, Marion Bankstahl, Steven R. Talbot, Joachim K. Krauss, Andre Bleich, Kerstin Schwabe · FENS Forum 2024
In rodent models with intracranial tumor formation, severity assessment and humane endpoint determination are fundamental for ethical and legal reasons. We here evaluated whether voluntary wheel running (VWR) would enable classification of severity after surgery for subcutaneous transmitter-implantation, intracranial tumor-cell-injection and resection, as well as humane endpoint detection. VWR behavior was compared to body weight, clinical state, together with heart rate (HR) and activity (Act) generated via transmitter. Male BDIX rats (n=14) were single-housed in cages equipped with a running
ePoster · Neuroscience