Topic: BDNF-TrkB signaling

The synergistic effects on neuronal plasticity of acute glucocorticoids levels increase and the BDNF-TRKB signaling indicate a deep interconnection between the two pathways. Moreover, chronic stress with elevated glucocorticoids levels and downregulation of TRKB signaling associated with reduced BDNF are both involved in the pathophysiology of different psychiatric disorders.In this study we investigated in vitro the molecular mechanisms underlying the interplay of glucocorticoids and TRKB signaling. We found that the glucocorticoid receptor physically interacts with TRKB, modulating its dimer