The effect of ergothioneine on synaptic plasticity in the hippocampal CA1 region using Alzheimer’s disease mouse model
Suk Yin Lee, Irwin Cheah, Barry Halliwell, Sajikumar Sreedharan · FENS Forum 2024
Studies have shown that ergothioneine (ergo), a derivative of histidine synthesized by certain fungi and actinobacteria, can protect against neuronal injury induced by exogenous Aβ. Our aim is to investigate the role of ergo in synaptic plasticity using the AD mouse model. Field electrophysiology was performed in the CA1 region of hippocampal slices from male C57BL/6 mice to measure synaptic modification over time. Hippocampal slices from the double transgenic AD mouse model APP/PS1, when stimulated with a strong tetanisation protocol, exhibit impaired late long-term potentiation (late-LTP), w
ePoster · Neuroscience