Characteristics of place field formation in the hippocampal CA1 and CA3 regions
Martin Blazsek, Kata Szamosfalvi, Snezana Raus Balind, Balázs Lükő, Gáspár Oláh, Máté Sümegi, Balázs Ujfalussy, Judit Makara · FENS Forum 2024
Hippocampal pyramidal cells (PCs) express spatially tuned activity (i.e., ‘place cells’ exhibiting ‘place fields’, PF) to support navigation. However, the cellular mechanisms of novel PF formation are elusive. Behavioral time scale synaptic plasticity (BTSP), recently described in mouse CA1PCs, is a putative mechanism of PF formation (Bittner et al., 2015). It starts with a silent PC exhibiting a large Ca2+ plateau in dendrites accompanied by somatic bursting, which initiates the emergence of tuning near the location of induction. Consequently, activity is strongest during formation and lower
ePoster · Neuroscience