The dynamic state of a prefrontal-hypothalamic-midbrain circuit commands behavioural transitions
Mahsa Altafi, Changwan Chen, Mihaela-Anca Corbu, Aleksandra Trenk, Hanna van den Munkhof, Kristin Weineck, Franziska Bender, Marta Carus-Cadavieco, Alisa Bakhareva, Tatiana Korotkova, Alexey Ponomarenko · FENS Forum 2024
Innate behaviours such as food intake, social interaction, and novel objects exploration meet multiple needs adaptively and sequentially, suggesting the existence of a hitherto elusive brain dynamics, encoding possible upcoming behaviours. Using electrophysiological neuronal recordings in freely-behaving mice, support vector machine classification and multicolor optogenetics, we show that during behavioural transitions, possible upcoming behaviours are encoded by behaviour-related phase signatures of neuronal populations in lateral hypothalamus (LH) that are active near beta oscillation (15-30
ePoster · Neuroscience