Pharmacological inhibition of BET proteins hampers rotenone-induced oxidative damage in an in vitro model of Parkinson’s disease
Noemi Martella, Daniele Pensabene, Mayra Colardo, Michela Varone, Arianna Mazzoli, Maurizio Muzzi, Sandra Moreno, Marco Segatto · FENS Forum 2024
Physiological levels of reactive oxygen species (ROS) are required for the proper regulation of biological functions and cell signaling. However, ROS overproduction and inadequate scavenging lead to oxidative stress and consequent damage to macromolecules. Recent evidence has demonstrated the incontrovertible involvement of oxidative stress in the onset and progression of different central nervous system (CNS) disorders, including neurodegenerative events. For instance, redox disbalance together with α-synuclein aggregation and neuroinflammation, contributes to the loss of dopaminergic neurons
ePoster · Neuroscience