Topic: Beta-hydroxybutyrate

Psychiatric disorders have pathophysiological changes in dysfunction and altered neuroplasticity in the hippocampus and prefrontal cortex (PFC), while atypical antipsychotics are able to modulate neuroplasticity. It has been reported that exercise may upregulate brain-derived neurotrophic factor (BDNF) expression in the hippocampus through the action of beta-hydroxybutyrate. Previously, our study showed that plasma beta-hydroxybutyrate level was reduced by exercise, but significantly increased by exercise+risperidone co-treatment in juvenile female rats. Therefore, this study aimed to assess t