Exploring the impact of chemical and electrical stimulation on human-iPSCs-derived neural networks coupled to high-density arrays
Giulia Parodi, Giorgia Zanini, Linda Collo, Michela Chiappalone, Sergio Martinoia · FENS Forum 2024
In the brain, the neuronal activity is kept and controlled by a precise and well-defined “Excitatory/Inhibitory balance” among neurons, which holds importance in neurodegenerative and neurodevelopmental disorders. With the final aim of generating a reliable in vitro system of the human brain, this work was focused on the interplay between excitatory (E) and inhibitory (I) neurons in neural networks derived from human induced pluripotent stem cells (hiPSCs), deepening the critical role of heterogeneity. We exploited high-density Micro-Electrode Arrays (MEAs, 2304 electrodes) to explore two neur
ePoster · Neuroscience