Bridging integrator 1 (BIN1) isoforms expression in oligodendrocytes and their putative role in cell cycle regulation in sporadic Alzheimer’s disease
Wai Ting Ma, Sunny Hoi-Sang Yeung, Gerald Wai-Yeung Cheng, Kai-Hei Tse · FENS Forum 2024
Bridging Investigator 1 is a known c-Myc inhibitor highly enriched in oligodendrocytes (OL), and its genetic variant confers a strong risk for sporadic Alzheimer’s disease (AD). BIN1 expression is tightly regulated by the alternative splicing of 20 exons, resulting in twelve protein isoforms. In human brain, as a nucleocytoplasmic protein, BIN1 regulates tau endocytosis, but its canonical nuclear function as a cell cycle regulator remains unknown. We aim to characterize BIN1 expression in the OL population of AD brains. To investigate, BIN1 expression was examined in two cohorts of post-mortem
ePoster · Neuroscience