Fitting, comparison and selection of different calmodulin kinetic schemes on a single data set using non-linear mixed effects modelling
Domas Linkevicius, Guido Faas, Angus Chadwick, Melanie I. Stefan, David C. Sterratt · FENS Forum 2024
Calmodulin (CaM) is one of the key neuronal calcium binding proteins that is essential in calcium signalling (Xia and Storm, 2005; https://doi.org/10.1038/nrn1647). Reflecting its importance, there are many different computational kinetic calcium-CaM models (Heil et al., 2018; https://doi.org/10.1101/254094). However, there has been no quantitative comparison and evaluation of these models, with some publications not reporting their training and validation performance. Moreover, there is no comparison on a common benchmark data set as is common practice in other modeling domains.We quantitativ
ePoster · Neuroscience