Topic: binge eating

Nicotinic acetylcholine receptors (nAChRs) are pentameric ionotropic receptors composed of a combination of α and β subunits. Human genetic association and preclinical studies have shown a key role of α5 containing nAChRs (α5*nAChRs) in the risk to develop nicotine addiction. Tobacco smoking is highly comorbid with bulimia nervosa and binge eating disorders. Interestingly, genetic variation at CHRNA5 has also been associated with higher body mass index (BMI) in never smokers, but lower BMI in current smokers, and increased appetence for food in rodents. Here we sought to investigate the role o

Overconsumption of ultra-processed food and sedentary lifestyle are the main causes of obesity, which in turn, increases the risk of developing metabolic, cardiovascular, and psychiatric diseases. Loss of control over food intake and binge eating often worsen as obesity progresses. Many studies have shown the effect of obesity on gut-microbiota composition and inflammation. However, less is known about microbiota and central adaptations occurring during the initial phases of body weight gain. To address this question, we used a rat model of binge eating, in which, rats (C/P) were fed twice a w