Compromised binocular vision and reduced binocularity in the visual cortex of postsynaptic density 95 (PSD-95) knock-out mice
Siegrid Löwel, Subhodeep Bhattacharya, Masoud Kargar, Oliver M. Schlüter, Cornelia Schöne, Nikolaos Aggelopoulos · FENS Forum 2024
Postsynaptic density protein 95 (PSD-95) is an important signalling scaffold of the PSD of excitatory synapses. We have previously shown that PSD-95 dependent silent synapse maturation closes the critical period (CP) for ocular dominance plasticity in mouse V1: PSD-95 KO mice display both functional & structural hallmarks of CP plasticity and synapses cannot properly stabilize. Since the development of binocularity happens during the CP, we hypothesized that PSD-95 KOs should display compromised binocular integration. To test this hypothesis, we performed both behavioural experiments and m
ePoster · Neuroscience