Topic: bioinformatic analysis

Extracellular vesicles (EVs) are membrane-enveloped nanoparticles released into the extracellular space by almost all cell types. They have been shown to spread α-synuclein (αSyn) – the main pathological hallmark of Parkinson´s disease (PD) – and miRNAs that can influence the expression of genes associated with PD progression. On this basis, they are becoming interesting as diagnostic biomarkers. So far, however, data from patients are heterogeneous and inconsistent. Therefore, we aim to use a cellular model that allows us to investigate the role of EVs in PD pathology on a homogeneous genetic