Temporal development of spontaneous seizures and seizure threshold after neonatal asphyxia and the effect of prophylactic treatment with midazolam in rats
Ricardo Schmidt, Björn Welzel, Annika Merten, Hannah Naundorf, Wolfgang Löscher · FENS Forum 2024
Birth asphyxia (BA) is one of the most serious birth complications affecting infants and can result in severe disabilities including mental retardation, cerebral palsy, and epilepsy. Animal models of BA and subsequent hypoxic-ischemic encephalopathy (HIE) are important to characterize functional and behavioral correlates of injury, explore underlying mechanisms, and assess the potential of novel therapeutic strategies. Using a non-invasive, physiologically validated rat model of BA and acute neonatal seizures that mimics many features of BA and HIE in human infants we studied (i) the temporal
ePoster · Neuroscience