Topic: birthdated neurons

Memories are dynamic constructs whose properties change with time and experience. The biological mechanisms underpinning these dynamics remain elusive, particularly concerning how shifts in the composition of memory-encoding neuronal ensembles influence a memory properties’ evolution over time. Here we leveraged a developmental approach to target distinct subpopulations of principal neurons (“birthdated neurons”), and used calcium imaging, optogenetics, chemogenetics, in association with multiple hippocampus-dependent learning tasks to investigate their contribution to memory engrams over time