Topic: bistable-critical-synchronization dynamics

Inhibitory deficits and an excitation/inhibition(E/I) imbalance arising from loss of inhibitory synapses may predispose to subclinical-epileptiform-activity and contribute to the earliest stages of Alzheimer’s disease(AD), and progressively lead to macroscopic neuronal network dysfunction. The classical brain-criticality-hypothesis posits that neuronal-systems operate at a continuous, second-order phase-transition with E/I-balance serving as primary control parameter. However, we have recently found neuronal systems in vivo may also operate at a discontinuous, first-order phase-transition and