Topic: blazed oblique plane microscopy

Due to the size and opacity of vertebrate brains, it has until now been impossible to simultaneously image neuronal circuits at cellular resolution across the entire adult brain. Thus, any recording is an implicit subsampling of the total activity, be it by local averaging (e.g. mesoscopic calcium imaging, fMRI), local sampling (e.g.multi-photon microscopy), or spatially distributed sparse sampling (e.g. electrode arrays). Understanding the precise relationship between these different sampling strategies has been a major challenge in neuroscience. Importantly, it is unknown how to trade off th