Topic: blood-brain-barrier breakdown

Sepsis is a life-threatening organ dysfunction caused by an exacerbated inflammatory response to an infection. This multifactorial syndrome includes loss of hemodynamic coherence, increasing permeability and blood-brain-barrier breakdown, neuronal death, etc. The presence of cognitive deficits increases mortality. It is defined as sepsis-associated encephalopathy (SAE). Glial cells, such as astrocytes, and mostly the microglia, coordinate the immune response in the brain and are indispensable to SAE pathophysiology. This response occurs through cell signaling via cytokines, such as chemokine C