Topic: Blood-brain barrier disruption

Much progress has been made in understanding the dynamics of spontaneous epileptic seizures [1], while an understanding of why and how the disease develops (epileptogenesis) remains elusive. Here, we present a first-of-its-kind model of epileptogenesis describing the interactions between neuroinflammation, blood-brain barrier disruption, neuronal death, circuit remodeling, and seizures. The model is formulated as a system of nonlinear differential equations describing processes acting on realistic timescales ranging from seconds to weeks. Mathematically, it is characterized by two stable fixed