Myeloid cells coordinately induce glioma cell-intrinsic and -extrinsic pathways for chemoresistance via GP130 signaling
Roland Kälin, Jiying Cheng, Min Li, Edyta Motta, Deivi Barci, Wangyang Song, Ding Zhou, Gen Li, Brian D. Vaillant, Hiroshi Katayama, Krishna P. L. B Bhat, Charlotte Flüh, Rainer Glass · FENS Forum 2024
Chemotherapy with Temozolomide (TMZ) is a mainstay for the treatment of primary brain tumors (glioblastomas; GBM). However, drug efficacy is reduced through a profound ability of GBM cells for DNA-repair and by the blood tumor barrier (BTB), which restricts intratumoral TMZ accumulation. Coherently, GBM almost invariably relapse with fatal outcome. We here show that GBM associated myeloid cells (GAM) simultaneously induce chemoresistance on the genetic and the vascular level by activating GP130 receptor signaling, which can be addressed therapeutically. After performing transcriptomic screens
ePoster · Neuroscience