Role of the dorsal vagal complex in semaglutide-induced reduction of food intake and body weight
Júlia Teixidor Deulofeu, Sebastian Blid Sköldheden, Ferran Font Gironès, Andrej Feješ, Johan Ruud, Linda Engström Ruud · FENS Forum 2024
The long-acting GLP-1 analogue semaglutide has revolutionized the pharmacological treatment of obesity, but the brain-mediated mechanisms behind the body weight loss and its most common side effect, nausea, remain unclear. By using select delivery of a Cre-dependent viral vector encoding hM3DGq and mCherry into the dorsal vagal complex (DVC) of TRAP2 mice, we here show that neurons in the DVC that are activated by semaglutide have direct projections to a variety of brainstem and forebrain structures involved in appetite regulation and visceral malaise. CNO-mediated re-activation of DVC neurons
ePoster · Neuroscience