Topic: brain dystrophins

Duchenne muscular dystrophy (DMD) is a neuromuscular syndrome caused by mutations within the DMD gene. DMD is associated with intellectual disability, behavioral disturbances and neuropsychiatric disorders. The presence and severity of these disorders, particularly social behavior disorders, seem to vary according to the position of the mutations affecting one or more brain dystrophins. However, the genotype-phenotype relationships underlying these troubles are not defined. In this study, we explored the involvement of brain dystrophins in social disorders using several DMD mouse models. We us