Light-dependent cAMP modulation in astrocytes triggers synaptic potentiation, hemodynamic responses, and behavioural changes in mice: Role in Huntington’s disease
Laia Sitjà Roqueta, Neville M. Ngum, Evgenii Zherebtsov, Melike Küçükerden, Sara Conde-Berriozabal, Anna Castañé, Manuel J. Rodríguez, Jordi Alberch, Deniz Dalkara, Andreas Möglich, Alexander Bykov, Igor Meglinski, H. Rheinallt Parri, Mercè Masana · FENS Forum 2024
Astrocytes are glial cells that participate in crucial processes in brain homeostasis and play a key role in modulating neuronal activity. Numerous astrocytic receptors transduce signals via cAMP although how changes in astrocytic cAMP levels modulate brain activity or animal behaviour is not fully understood. Our goal is to control cAMP in cortical astrocytes using DdPAC, a recently developed phytochrome photoreceptor that increases cAMP upon red light, and evaluate its responses at three levels: a) cellular, by analysing neuronal activity using multi-electrode arrays b) systemic, by measurin
ePoster · Neuroscience