Label-free biomolecular spectroscopy with vibrational fiber photometry deep in the mouse brain
Filippo Pisano, Mariam Masmudi-Martìn, Maria Samuela Andriani, Elena Cid, Marco Pisanello, Antonio Balena, Liam Collard, Teresa Jurado Parras, Marco Bianco, Mohammadrahim Kazemzadeh, Patricia Baena, Francesco Tantussi, Marco Grande, Leonardo Sileo, Francesco Gentile, Francesco De Angelis, Massimo De Vittorio, Liset Menendez de la Prida, Manuel Valiente, Ferruccio Pisanello · FENS Forum 2024
Optical approaches for in vivo neural monitoring, using genetically encoded molecular reporters, offer a precious window on brain functions and on its mechanisms of development, ageing or disease progression. Nonetheless, the existing methods are still shortsighted with respect to the complex biomolecular alterations that accompany these physiological and pathological dynamics. As a result, our grasp of the multifaceted components of brain activity is still partial. To mitigate this limitation, we propose a fiber photometry method based on spontaneous Raman scattering – which we call vibration
ePoster · Neuroscience