Bidirectional manipulation of orexinergic neurons shows sexual dimorphism in learning and memory
Alexis Vega Medina, Joelle Chiu, John N. Neeley, Anna Wirthlin, Nejra Terzic, Miles Hirsch, Sara J. Saton · FENS Forum 2024
Sleep deprivation is thought to affect 30% of the population worldwide. Yet our understanding of how sleep disorders develop, how to treat them, and how to prevent cognitive impairment associated with lack of sleep remains limited. Previous studies from our lab have suggested that orexinergic inputs to the hippocampus are more active when mice are sleep deprived, but whether this plays a role in the mechanism for disruption of hippocampal memories during sleep deprivation is unknown. We have used excitatory and inhibitory chemogenetic manipulations to bidirectionally modulate orexin neurons' a
ePoster · Neuroscience