Correlation between motoneuronal survival and VEGF expression in brainstem motoneurons in the SOD1 ALS murine model
Silvia Silva Hucha, M. Estrella Fernández de Sevilla, Kirsty M Humphreys, Fiona E Benson, Ángel M Pastor, Sara Morcuende · FENS Forum 2024
ALS is a progressive neurodegenerative disease characterised by the loss of motoneurons (MNs). Some MNs present a lower vulnerability to the disease, including neurons of the oculomotor system (OCM), compared to other cranial MNs (facial or hypoglossal). Vascular endothelial growth factor (VEGF) has shown the ability to protect MNs from degeneration. Overexpression of VEGF is involved in neuroprotection and delayed neurodegeneration of MNs. We have previously described a higher amount of VEGF in the extraocular neurons in control adult rats. The objective of this study in the murine SOD1G93A A
ePoster · Neuroscience