Topic: BTG anti-proliferation factor 2

Neuropathic pain is an intractable disease which in case opioids provide inadequate analgesia. It has been previously reported that voluntary wheel running prevented persistent hyperalgesia in sciatic nerve ligation (PSNL) mice. However, the mechanism of the preventive effect of the voluntary wheel running on persistent hyperalgesia was unknown. Since the anterior cingulate cortex (ACC) has been known to play an important role in chronic pain, we investigated factors associated with the attenuated hypersensitivity on voluntary wheel running in the ACC of the PSNL mice.A partial sciatic nerve l