Enriched phenotype analysis: Tying perineuronal net structures to high and low burrowers in isolated and enrichedly housed rats
Jane Morphett, Alexandra Whittaker, Mark Hutchinson · FENS Forum 2024
Affective state has influence over behaviour and cognition. A negative affective state compromises health and immune response. The extracellular matrix, a lesser understood region of the brain, potentially provides mechanisms for change in mood states. Mood disorders associate with change in plasticity; specifically, perineuronal nets (PNNs) associate with synaptic plasticity. PNNs mostly surround Parvalbumin neurons (PV) thereby altering inhibitory signalling.The aim of this study was to induce a positive or negative affective state in rats through housing conditions, validate this with behav
ePoster · Neuroscience