Inhibition of PI3K/Akt/mTOR pathway modulates LPS-induced metabolic changes in microglia
Katarina Milosevic, Ana Milosevic, Ivana Stevanovic, Anica Zivkovic, Marija M. Janjic, Ivana Bjelobaba, Irena Lavrnja, Danijela Savic · FENS Forum 2024
Microglia are metabolically flexible cells able to respond to environmental changes by reprogramming their intracellular metabolic pathway subsequently altering immune function. Exposure to inflammatory stimuli increases microglial reliance on aerobic glycolysis, a key metabolic adaptation required for their pro-inflammatory activation. There is evidence that the PI3K/Akt signaling pathway activates hypoxia-inducible factor-1α (HIF-1α) via its target mTOR, and HIF-1α is known for its regulatory function in metabolism and immunity. Therefore, we investigated agmatine (Agm) as a potential modula
ePoster · Neuroscience