Topic: C-C Motif Chemokine Ligand 5

Traumatic brain injury causes axon tearing and synapse degeneration resulting in multiple neurological dysfunctions and early neurodegenerations; the repair of axonal and synapse structures is critical in maintaining neuronal function. C-C Motif Chemokine Ligand 5 (CCL5) shows neuroprotective function by promoting neurite outgrowth and synaptogenesis. This study used a weight-drop model to induce mild brain trauma in both C57BL/6 (wildtype, WT) and CCL5 knockout (CCL5-KO) mice. The recovery of motor and sensory neurological functions, and synapse structure and proteins were impaired in CCL5-KO