The early cognitive decline in Alzheimer's disease models is linked to changes in the intrinsic excitability of the prefrontal cortex
Senka Hadzibegovic, Viviana Villicana Munoz, Francesca Bettoni, Melanie Ginger, Liangying Zhu, Olivier Nicole, Bruno Bontempi, Andreas Frick · FENS Forum 2024
Achieving early diagnosis in Alzheimer's disease (AD) is a crucial objective in preclinical and clinical AD research, since it represents a therapeutic window during which interventions can be initiated before the onset of severe cognitive decline. Accumulation of amyloid-beta (Aß) in the prefrontal cortex is linked to rapid forgetting in this prodromal AD stage. Thus, early forgetting becomes a potential target for preclinical studies seeking to prevent/delay the onset of severe forms of AD. We used mouse models to identify early alterations in memory formation. Our findings indicate that Aβ1
ePoster · Neuroscience