Self-degradation of memory in Alzheimer’s disease: Experimental testing of the hypothesis and search for methods of neuroprotection
Konstantin Anokhin, Ksenia Toropova, Olga Rogozhnikova, Tatiana Zamorina, Anna Ivanova, Olga Ivashkina · FENS Forum 2024
Alzheimer's disease (AD) is characterized by a dramatic loss of old consolidated memory. Our study proposes a new hypothesis that neurodegeneration affects mechanisms of memory reconsolidation, leading to the weakening of old memories when they are retrieved in the diseased brain, resulting in gradual self-degradation of the consolidated memory. Testing this hypothesis in transgenic 5xFAD mice we found that their contextual memory was impaired following retrieval compared to control animals. To protect memory during reconsolidation, we administered the NMDA receptor antagonist MK-801 which is
ePoster · Neuroscience