Topic: c-fos immunostaining

Psychedelics like psilocybin and ketamine have shown great potential in treating psychiatric disorders, often producing long-lasting effects after a single dose, yet their underlying neural mechanisms remain poorly understood. Since one of the most consistent features of the psychedelic experience is the alteration in perception, this study aimed to investigate how acute doses of psychedelics influence perceptual integration. We used a free-response perceptual integration task in mice, alongside brain-wide mapping of drug-responsive populations using activity-dependent gene expression and calc