Topic: C-Src

The lysosomal membrane protein, TMEM106b, has been identified as a risk factor for frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP). Although the cellular function of TMEM106b is poorly understood, it has been shown to regulate lysosomal morphology and trafficking and autophagy in neurons. Recently, there has been interest in the discovery of TMEM106b amyloid fibrils formed by its lumenal C-terminus, which have been observed in various neurodegenerative disorders and healthy aged brain. In a high-throughput phosphoproteomic screen, we identified TMEM106b as a substrate for t